At present the train running performance on large span bridges with multiple-track line has caught great attention, and its modeling and analysis of vehicle-bridge coupling vibration has major engineering value. Taking a four line bridge as background, the baseline finite element model was set up by measured modal parameters and related design materials. Then based on this model, system motion equation of vehicle-bridge was formulated using modal superposition method according to the rigid contact relationship of the wheel and rail in the normal direction. Besides, the model was validated by comparing the results of operation bridge test and numerical simulation. At last, the vehicle-bridge coupling vibration analysis under different working conditions was carried out, and the dynamic response of the bridge and vehicle, as well as the operation safety and stability were evaluated, some useful conclusions with engineering values are drawn.