Liquefaction of sand is the main cause of failure for earth structure during the earthquake. Some past research showed that fabric anisotropy of sand due to contact normal distribution and particle shape may affect the seismic response. Current assessment of liquefaction potential did not account for the fabric anisotropic so that the settlement of structure could not be predicted reasonably. To explore the effects of fabric anisotropy on dynamic response of strip foundation and anisotropic ground, in this study, six centrifuge tests were performed on scaled model by ground prepared in different deposition angles. A special rigid container was designed and used to prepare models with different directions of soil deposition. It was found that fabric anisotropy significantly influenced the dynamic response of strip foundation and ground. The liquefaction resistance of model of 90°is lower than those of other models from observation of acceleration and pore pressure evolution, which were indicated by serious settlement and residual horizontal displacement. The results recommended that to precisely predict the dynamic performance of structure, the effect of fabric anisotropy on dynamic response of ground should be incorporated in the conventional design method, which significantly affected the settlement and liquefaction resistance of ground.