Aiming at the loading features of the asymmetric double tower high-rise connected structure and the roughly stationary under the large earthquake, the connected structural calculation model under five connection methods was established with the serial-parallel system of particles storey model, and the coupling characteristics of the connected structure under different connection methods were discussed and explored. The stationary random response of the connected structure under different connection methods was solved with the combination of state space analysis method, equivalent linearization of Bouc-Wen model and the pseudo excitation method. The dynamical reliability of the high-rise connected structure in small and major earthquakes, as well as the change rule for the dynamical reliability of connected structure under the power spectrum function of small and large earthquakes owning to different connection methods was discussed in details by taking advantage of the random response obtained and dynamic reliability theory, the Monte Carlo method is validated calculations for the given model. According to the research results, the power-wasting flexible connection method has a distinct effect on improving the structural dynamical reliability under small earthquakes, while it has little influence on the reliability of tower under large earthquakes; however, it has a huge influence on the connection reliability. When the non-power wasting connection method is adopted, the strengthening connection type with the connection and tower has a significance influence on the reliability of the adjacent tower, and the causes to the results have been analyzed, which will provide some reference for the practical engineering application and researches.