In this paper, the unified description method of state space with different dampers for structural arrangement is derived. Based on this, a genetic algorithm is used to realize the synchronous optimization of a fixed number of different types of dampers. The transformation matrix is used to convert the influence of the damper on the floor to the floor response, and the coefficient matrix corresponding to different types of dampers in the state space equation is derived, and the motion equation is transformed into a unified expression of the state space method. Combined with the genetic algorithm, the representation of the feasible solution has a wide range of features, and the structure of the different types of dampers is uniformly coded to achieve synchronous optimization. A fixed-type damper optimization arrangement of 6-layer and 20-layer frame structures is carried out by this method. The comparison results with the existing research results are obtained, and the consistent optimization results are obtained. The feasibility of the proposed method is verified. The same structure is fixed with the same total number of two types of dampers. The optimization effect is similar to that of the same type of damper, and it is better than other arrangements. It proves the effectiveness of the proposed method in the simultaneous optimization of different types of dampers. The method combines the advantages of unified description of the problem by state space method and the advantage of global search of optimal solution by genetic algorithm. It can optimize multiple different types of damper positions in a short time, and intelligent optimization represented by genetic algorithm. The application of the algorithm in the field of civil engineering has certain theoretical value, and it has certain guiding significance for the practical engineering application of the optimal arrangement of the damper.