The meshless methods based on point interpolation method，radial point interpolation method and nose-based smoothed point interpolation method are proposed for dynamic analysis of a hub-beam system. Based on the floating frame of reference formulation，the longitudinal and transverse deformations of the beam are both considered. The coupling term of the deformation，which is caused by the transverse deformation，is also included. The second Lagrange equation is employed to derive the dynamic equations of the hub-beam system with large overall motion. Simulation results of the meshless methods are compared with those obtained by using finite element method and assumed mode method. It is demonstrated that the meshless methods can be extended in the field of rigid-flexible coupled system with a hub-beam.