In view of the weak seismic components of subway underground station structure， the seismic response characteristics of the traditional station structure， the station structure with the elastic sliding bearing setting at the top of the middle columns on the top and ground floor， and the proposed station structure with the elastic sliding bearing setting at the edge of the middle plate and the middle columns on the ground floor are studied. A 2D global time-domain finite element analysis model is built for the nonlinear statically and dynamically coupled soil-main structure interaction. The influence rules of the interlayer displacement， angle， seismic damage and dynamic force response of the main structure of the station are compared and analyzed when different isolating systems are adopted. The results show that，compared with the traditional station structure， the station structure with the elastic sliding bearing setting at the top of the middle columns suffers less damage in earthquake and has better seismic performance. The station structure with the elastic sliding bearing setting at the edge of the middle plate and the middle columns on the ground floor proposed in this paper can ensure that the middle columns of the station structure are not severely damaged and can be replaced quickly after the earthquake， which can improve the overall seismic performance of the subway station structure and the rapid recovery ability of the structural function after the earthquake.