To reveal the seismic behavior of Gurbantonggut desert sand concrete frame joints （DSCJ）， quasi-static tests are carried out on nine 1/2-scale DSCJs. The failure phenomenon and mode， hysteresis performance， energy dissipation capacity， ductility，stiffness and restoring force models of DSCJ are investigated considering the desert sand replacement ratio， axial compression ratio， and stirrup ratio. Test results show that when the desert sand replacement ratio increases from 0%，20%，40%，60% and 80%， the failure phenomenon， skeleton curve， energy consumption and stiffness degradation of the specimens are mainly determined by the strength and stress-strain constitutive relationship of desert sand concrete， and the ductility decreases gradually，which decreases by 11.48% with the of 80% . When the axial compression ratio increases from 0.2，0.4 and 0.6， the peak load increases by about 3%， the ductility decreases by about 5%， the equivalent viscous damping coefficient increases by about 18%，and the stiffness degradation increases gradually. When the stirrup ratio increases from 0.50%，1.57% and 2.52%， the peak load increases by about 10%， the ductility increases by about 6%， the equivalent viscous damping coefficient increases by about 25%，and the stiffness degradation decreases gradually. In summary， the seismic performance of DSCJ is similar to that of ordinary concrete specimens， showing better energy dissipation capacity. The three-fold line restoring force model of DSCJ is established， and the calculated model agrees well with the experimental results. This study could provide a basis for the engineering application of DSCJ.