The traditional interlayer shear model of the building structure is not consistent with the real stress of the structure， and cannot accurately reflect the dynamic response of the actual multi-dimensional eccentric structure， so the engineering feasibility is not enough. The current simplified model building method of bending-shear is inefficient and cannot directly guide the modeling of three-dimensional eccentric structure. According to the basic principle of flexibility method in structural mechanics， a fast and accu? rate method for establishing interlayer flexural shear model is proposed. On this basis， considering the influence of the structure's eccentricity on the dynamic response of the structure， a three-dimensional bending-shear eccentricity model is established， and the effectiveness of the structural damping control under bidirectional and torsional seismic waves is verified by multidimensional timehistory analysis. The results show that the simplified three-dimensional flexural shear eccentricity model based on the flexibility method has the advantages of high modeling accuracy and computational efficiency， and can accurately reflect the dynamic response of the real structure under multi-dimensional earthquake action. The optimal arrangement of the tuned dampers after considering the actual eccentricity can fully exploit the damping performance.