In order to analyze the motion sickness of the driver on the long-span highway suspension bridge experiencing vertical vortex-induced-vibration (VIV), the one-dimensional vertical human body vibration model is first introduced into the traditional wind-vehicle-bridge coupled vibration model, and the simple harmonic vortex excitation model is used. The force model simulates the VIV of the bridge, and a wind-bridge-vehicle-human coupled vibration model of the long-span bridge experiencing VIV is established to calculate the human body vibration response. Subsequently, based on the international standard evaluation method ISO 2631-1:1997(E), a calculation method for driver’s motion sickness index based on human body vibration response is proposed. The above-mentioned refined algorithm requires a lot of computing resources and time, and in order to facilitate the practical engineering application, a simplified algorithm for quickly calculating the driver's human body vibration response and motion sickness index is also proposed. Afterwards, based on the wind-bridge-vehicle-human coupled vibration model, taking a long-span suspension bridge as an example, the vibration response of the vehicle and the driver's body on the bridge experiencing VIV is analyzed. To validate the feasibility of the simplified algorithm, a comparison is made between the human body vibration responses and motion sickness indicators of drivers on the bridge experiencing VIV calculated using the sophisticated algorithm and the simplified algorithm. The results indicate that the human-vehicle coupled vibration has barely no effect on the vibration of the vehicle travelling on the bridge under VIV. The discrepancy in vibration response between the human and the vehicle, as well as various parts of the human body, increases with the increase of VIV frequency. The computational efficiency of the simplified algorithm is very considerable and is feasible for practical engineering.