The vibration and noise of mechanical structures caused by transmission system is one of the key problems that need to be solved in the research of high-speed mechanical equipment. This study investigates the location and optimization of vibration and noise reduction of a high speed packaging machine transmission system based on coupling vibration and noise experiment and simu? lation analysis. The vibration and noise test device and the rigid-flexible coupling dynamic simulation model of the high-speed pack? aging machine's transfer mechanism and its transmission system is established. Based on the experimental data， the load identifica? tion is carried out and the accuracy and reliability of the model is verified. Based on the model， combined with modal participation factor and acoustic contribution analysis method， the modal frequency and plate area with large acoustic contribution of the highspeed packaging machine transmission system are analyzed， which improves and optimizes the design of the transmission system. The results show that modal contribution analysis and plate contribution analysis can locate the noise problem area quickly and accu? rately to serve the optimization of the corresponding mechanical structure design. The vibration and noise performance of the opti? mized high speed packaging machine drive system is improved significantly.