Aimed at the problem of limited placement of error microphones in large-scale spatial active noise reduction systems， this paper used the virtual error sensing technology to place multiple virtual error microphones in the noise reduction target area， and transferred the quiet zones from the physical error microphone points to the virtual error microphone points， expanded the range of the quiet zones in the noise reduction target area. In order to analyze and study the noise reduction performance and influ? encing factors， the principle and algorithm of multi-channel virtual error sensing were given first， and then the noise reduction per? formance and the number and placement of physical and virtual error microphones ware simulated and analyzed. Finally， the noise reduction performance and influencing factors were verified experimentally in a model cabin of a turboprop aircraft. The simulation and experimental results show that the used virtual error sensing was beneficial to increase the average noise reduction and quiet zone of the target noise reduction area， the placement of the physical and virtual error microphones directly affects the distribution of the quiet zones， a reasonable number and placement of physical and virtual error microphones can expand the quiet zones to cov? er the noise reduction target area 100%， and the optimal number of error microphones was related to the noise frequency character? istics of the primary sound field.