Abnormal vibration often occurs in the liquid oxygen kerosene transmission pipeline of the rocket engine， which serious? ly threatens the safety of the rocket engine. Improper handling will result in a failed rocket launch and enormous economic losses. Therefore， it is necessary to study the vibration of the transmission pipeline. In this paper， a three-dimensional high pressure trans? mission pipeline model comprising a corrugated pipe， a multi-section bending pipe and other auxiliary structures is established.Us? ing the two-way fluid-solid coupling method， the vibration analysis of the pipeline is performed under external pressure pulse excita? tion. The accuracy of the computation results is verified by a thermal test. The results show that at the same frequency， the ampli? tude distribution of vibration acceleration obviously correlates with the amplitude distribution of flow field pressure， which indicates that the fluid pressure fluctuation is the root cause of abnormal vibration of pipeline.And the vibration of pipeline increases with the increase of average pressure. In the visualization results， the location of pipeline vibration is mainly concentrated in the middle pipe? line and bellows. The stress and strain of the pipeline are concentrated at the bellows， bends and supports， which is different from the distribution of vibration acceleration. The position with large stress and strain is the dangerous position where the structure is prone to failure， which should be paid more attention to.