To broaden the site selection for nuclear power plants， it is vital to assess the seismic safety of nuclear power structures in non-rock sites with pile foundations. Current pile-soil-structure interaction analysis methods， such as the Winkler foundation model and the p-y method， simplify the interaction problem and struggle to reflect complex foundation situations. While the integral finite element method can consider complex foundation situations， it is computationally intensive and inefficient. This paper intro? duces an efficient three-dimensional time-domain method， Partitioned Analysis of Soil-Structure Interaction （PASSI）， which uses different time steps for pile foundation and soil to avoid unnecessary calculations. A three-dimensional finite element model of the pile-soil-nuclear power structure interaction is established， with the AP1000 nuclear island structure as the research object. The ef? fectiveness of this asynchronous algorithm is verified by inputting pulse waves， and the characteristics of the maximum shear force and bending moment of the pile are analyzed by combining the kinematic and inertial interactions. The response of the pile-soil-nu? clear power structure under the seismic wave input is then analyzed. Since the degrees of freedom of the pile are insignificant com? pared to the soil， the additional computational volume of the pile can be neglected when using the pile-soil asynchronous algorithm. This efficient method is expected to be used in the analysis of the dynamic interaction of large nuclear power structures with pilesoil-structures.