The seismic dynamic response of pile foundation in inclined liquefaction site is an important issue in the field of geotechni cal seismic engineering. Based on the shaking table model test carried out by our research group and the OpenSees software plat form， a two-dimensional integrated numerical model of inclined liquefied soil-pile group-structure interaction is established in this paper. The nonlinearity of pile-soil contact and the shear localization of soil layer are considered in the model. The rationality and ef fectiveness of the numerical simulation method are verified by comparing with the shaking table test results. On this basis， a typical inclined liquefied site-pile group-structure interaction finite element model is established to discuss the influence of different overly ing crust on the seismic response of site and structure system. The calculation results show that with the increase of the thickness of overlying crust， the pore pressure ratio in the saturated sand decreases， the horizontal residual displacement of soil decreases， and the displacement of pile body and the pile curvature decrease. The effect of the strength of overlying crust on the dynamic response of pile foundation is more obvious. The increase of the thickness of overlying crust can reduce the liquefaction degree of sand and improve the mechanical performance of pile foundation.