In order to study the size effect of the dynamic response of high-density polyethylene（HDPE）corrugated pipeline under blasting vibration，the blasting test and dynamic finite element numerical calculation method of full-size pre-buried pipelines are carried out，and the reliability of the numerical calculation model of HDPE pipeline dynamic response is analyzed through the vibration monitoring results during the test process. On this basis，the dynamic responses of the multi-diameter HDPE pipeline are calculated and analyzed to reveal the dynamic response characteristics of blasting vibration under the influence of buried high-density polyethylene corrugated pipelines size effects. The research results show that the vibration velocity and effective stress of the front blasting side of each section of the pipeline are greater than the back blasting side of the pipeline under the blasting vibration，the peak value of the pipeline vibration velocity appears at the bottom of the pipeline. As the diameter of the pipeline increases，the vibration velocity and effective stress of the pipeline will decrease accordingly. There are functional relationships between the peak effective stress of the pipeline and the peak particle velocity of the pipeline，and between the vibration velocity of the pipeline and the surface vibration velocity. According to the maximum allowable working pressure of the pipeline in the relevant specifications，the pipeline surface control vibration speeds of the HDPE corrugated pipeline（empty pipe）with pipe diameters of 40，50，60，80 and 100 cm are 22.51，20.91，19.70，17.91，16.64 cm/s，respectively.